They also have a variety of free webinars available on their website. In order to communicate between neurons, the nervous system produces chemical messengers called neurotransmitters. Organic acids with one carboxylic acid have one conjugate base while some organic acids may have two or three carboxylic acids and two or three conjugate bases. ENVIROtox: GPL-TOX + OAT + … These missing or malfunctioning enzymes prevent important biochemical reactions from occurring and cause metabolites (including organic acids) to accumulate (1). MMA then builds up in the blood and is eventually excreted in the urine, where it can be detected by an organic acid test. Since utilizing the OAT, it has provided me with a variety of information to determine the underlying cause of female related issues. Although some organic acidemias result in lowered blood pH, other organic acidemias are associated with organic acids that are relatively weak and do not typically cause acidosis. Clostridia. I love when I can identify a biochemical glitch and someone can have such a profound emotional turn around. It can also be used to identify subclinical (non-symptomatic) metabolic imbalances in order to PREVENT chronic illness from developing. Organic acids are byproducts of metabolism that provide insights on how different bodily systems are performing. Learn more about OAT So interesting! The OAT test is an at home urine collection kit and is available in most states, and for international purchase. Because it only requires the collection of a urine sample, OAT is quick and painless for patients. What Does a Urine Organic Acids Test Evaluate? Listen to The Lab Report podca… Every organic acid has one or more conjugate bases named with the suffix –ate. Organic acidemias are disorders of intermediary metabolism that lead to the accumulation of toxic compounds that derange multiple intracellular biochemical pathways including glucose catabolism (glycolysis), glucose synthesis (gluconeogenesis), amino acid and ammonia metabolism, purine and pyrimidine metabolism, and fat metabolism. Some organic acidemias may be chronic and present in the first few days of life. 3. For example, elevated levels of the organic acid methylmalonic acid (MMA) in the urine are a well-validated indicator of vitamin B12 deficiency (17). Anyone who suffers from a chronic health condition or who simply wants to gain insight into their overall metabolic health is likely to benefit from OAT. We use the following tests: Amino Acids - Urine Test. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, … Biometrix Labs Urine Organic Acid Testing About Organic Acids Organic Acids are chemical compounds which are used in essential metabolic processes of the body, these metabolic processes govern how your body changes food into the energy the body needs to … The sample is then frozen and shipped to the laboratory, where organic acids are measured from the urine sample using liquid or gas chromatography-mass spectrometry (131). Other inborn errors of metabolism can also be detected by urinary organic acids, including: In the United States, all newborns are screened for these diseases, so they’re usually diagnosed quickly (15). I need to find someone who take medicare to evaluate my results. While many labs offer a variety of organic acid tests, two companies are most popular: The Organic Acids Test from Great Plains Laboratory evaluates over 70 different organic acids. An OAT tests a multitude of organic acids that are byproducts of daily cellular metabolism. More recently, scientists have learned that less severe mitochondrial dysfunction plays a role in many chronic conditions, including cancer, diabetes, epilepsy, and neurodegenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s disease (69, 70, 71, 72, 73). Nutritional factors include deficiency in coenzyme Q10, carnitine, riboflavin, thiamin, niacin, vitamin B12, iron, magnesium, or manganese, all of which are required for cellular respiration (energy production) in the mitochondria (85, 86, 87, 88). Erica and Amy are experienced registered dietitians who are passionate about creating great nutrition content! I have been so impressed by this test that I can't help but want to spread the word about its uses for various women's health conditions!". I never would have thought to refer people to having an OAT test done. When you fast or consume a very low-carbohydrate diet, the body naturally produces ketones to be used for energy instead. Mycotoxins (MYCO-TOX) - Urine Test. Thanks for sharing! If there is a deficiency or dysfunction in a metabolic pathway, there will be an accumulation of an organic acid, that spills into the urine. Functional markers of neurotransmitter metabolism that can be measured in the urine include: Again, these results are just a starting point for further investigation. Genova Diagnostics has a test called the Organix Basic Profile that includes more than 30 different OAs. Vitamin D Test. At certain levels, organic acids in urine may be indicators of toxicity or “markers” of the function of metabolic pathways. I hope that many practitioners start using OAT tests as they are very helpful. Organic acid testing is one of the best ways to test for mitochondrial dysfunction, since it measures most of the intermediates in the citric acid cycle (65, 74, 75, 76). Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids. Organic acid testing can also be used to detect deficiency (or insufficiency) of certain B vitamins. However, there are some limitations to consider when deciding whether OAT is right for you: 1. Sign up with your email address to receive news and updates. By testing for organic acid concentrations in the urine, can indicate a compromise of a major metabolic pathway that can … The OAT Panel complements the … Thankfully, our bodies can use antioxidants to destroy free radicals and counteract oxidative stress (92, 93). This article was a joint-venture, written by both Erica Julson, MS, RDN, CLT (owner/founder) and Amy Richter, MS, RDN, LD, CLT (lead writer). The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with 76 markers. A skilled practitioner can look at the bigger picture to find patterns that point to possible root causes. The Organic Acids Test (OAT) examines metabolites (chemical substances produced by your metabolism) that are coming out with, and in, your urine. It also evaluates oxalate toxicity, as well as mitochondria function, and various […] Organic Acids Test – clinically significant areas Yeast & Bacteria. Organic acids are produced by bacteria in the gut as they metabolize various components of the foods we eat. At certain levels, organic acids in urine may be indicators … These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. The resulting organic acids are used by the body to generate cellular energy and provide many of the building blocks necessary for cell function. Price varies for international OAT kits – please contact our laboratory for more information on international kits. Thank you so much Sarah! This test has allowed me to investigate more deeply the chronic issues that contribute to female related conditions like PMS, uterine fibroids, endometriosis, chronic UTIs and vulvodynia. Depending on which OAs are being measured, the instructions might require you to avoid certain foods and supplements for a couple of days leading up to the test as well. ENVIRO-TOX Panel - Urine Test metabolic, nutritional, and neurological disorders. Combine the OAT Test and Amino Acids Urine test (random sample) and save! The main difference between the two is that the Basic Profile does not include any of the OAs that serve as markers for bacteria and fungi. It is rarely used in isolation, and additional testing is usually ordered after looking at the results. Great Plains Urine Organic Acid Test: The Organic Acids Test (OAT) Provides A Metabolic Snapshot based on the products the body discards through the urine. Many organic acidemias are associated with slight to marked increases in plasma ammonia. The main reasons for abnormal urinary organic acid results include: We’ll review each of these scenarios in detail below. Learn how your comment data is processed. Organic acid testing is still mostly used for the diagnosis of these disorders, but the science has progressed, and now we can use OAT to evaluate overall metabolic health as well. However, in all of these cases, blood tests are more reliable and your doctor is likely to order them for confirmation. Click here to get a PDF copy delivered to your inbox. AD(H)D Panel. After 2 days, he said his depression virtually disappeared and he was no longer suicidal. These include: Elevated levels can be due to genetic mutations or deficiencies in required nutrients like thiamin, lipoic acid, CoQ10, pantothenic acid, riboflavin, or niacin (46, 47, 48, 49, 50, 51). Inborn errors of metabolism are another common cause (, When you fast or consume a very low-carbohydrate diet, the body naturally produces ketones to be used for energy instead, These ketones can be detected in the urine with organic acid testing, Elevated levels can be due to genetic mutations or deficiencies in required nutrients like thiamin, lipoic acid, CoQ10, pantothenic acid, riboflavin, or niacin (, Urinary levels of these organic acids can be impacted by things like genetic snps, nutrient deficiencies, diet, exposure to environmental toxins, stress, sleep, neuroendocrine tumors, supplements, and adrenal function (, Mitochondrial dysfunction (when mitochondria do not produce energy at their optimal rate) can be caused by genetic disorders, inadequate nutrition, inflammation, environmental toxins, medications, viral infections, and DNA damage (, More recently, scientists have learned that less severe mitochondrial dysfunction plays a role in many chronic conditions, including cancer, diabetes, epilepsy, and neurodegenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s disease (, Organic acid testing is one of the best ways to test for mitochondrial dysfunction, since it measures most of the intermediates in the citric acid cycle (, Nutritional factors include deficiency in coenzyme Q10, carnitine, riboflavin, thiamin, niacin, vitamin B12, iron, magnesium, or manganese, all of which are required for cellular respiration (energy production) in the mitochondria (, Oxidative stress occurs when there is an imbalance between free radicals and antioxidants within the body (, Free radicals are unstable atoms that steal electrons from other molecules, leading to cellular damage (, High levels of free radicals and oxidative stress contribute to chronic diseases like cancer and heart disease (, Thankfully, our bodies can use antioxidants to destroy free radicals and counteract oxidative stress (, pyroglutamic acid and 2-hydroxybutyric acid (, Urinary organic acids related to detoxification and/or liver and kidney function that are commonly measured on OATs include (, Reducing exposure to environmental toxins, Correcting nutrient deficiencies that may impair these pathways (glycine, glutamine, taurine, cysteine, methionine, pantothenic acid, riboflavin, niacin, vitamin B6, folate, vitamin B12)  (, Adding foods or supplements to the diet that enhance the body’s natural detoxification abilities (magnesium, NAC, zinc, selenium, copper, manganese, antioxidants, thiols, etc.) Organic acids that can indicate possible vitamin B deficiencies when out of range include: However, many of these markers have other factors that can increase or decrease their levels, so proper test prep and interpretation is important. I would look at the database of practitioners at https://www.ifnacademy.com/meet-the-experts/meet-our-grads/ – hope that helps! The most commonly measured organic acids related to impaired fat metabolism are: Possible nutrition-related reasons for poor fatty acid metabolism include carnitine and/or riboflavin deficiency or increased need for these nutrients due to genetic variants. This profile assesses major metabolic areas that may be compromised by common lifestyle and dietary factors, such as nutrient deficiencies, toxicity, bacterial overgrowth, or medications. Without enough of these nutritional cofactors (or if someone has genetic mutations that affect how well their enzymes work), these chemical pathways are unable to proceed at their normal pace. Organic acids are a broad class of compounds formed during fundamental metabolic processes in the body. These ketones can be detected in the urine with organic acid testing: Even when not in ketosis, high levels of other urinary organic acids can identify possible issues with carbohydrate metabolism. Dr. Jenny … The Organix Comprehensive Profile offers a more detailed evaluation, with over 40 OAs. It provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. These organic acids can be measured in the urine via routine screening tests. This video gives an overview of what we should see on the DUTCH Complete™ report. Many genetic disorders are caused by the production of an inefficient enzyme that reacts at a slower than usual rate, resulting in an accumulation of a metabolic intermediate. For example, one of the better known inborn errors of metabolism is phenylketonuria (PKU). Clinical presentations of organic acidemias vary widely and may include failure to thrive, intellectual development disorders, hypo- or hyperglycemia, encephalopathy, lethargy, hyperactivity, seizures, dermatitis, dysmorphic facial features, microcephaly, macrocephaly, anemia and/or immune deficiency with frequent infections, ketosis and/or lactic acidosis, hearing, speech, or visual impairment, peripheral neuropathy, sudden cardiorespiratory arrest, nau­sea and coma. It is definitely a labor of love . Organic acids are organic compounds that are acidic. Combine the OAT Test (urine) and Food Map w/Candida + Yeast (blood spot) and save! The OAT test is a urine test that is performed in the convenience of your own home. High levels of free radicals and oxidative stress contribute to chronic diseases like cancer and heart disease (91). Click here to learn more about the how's and why's of testing your hormones. Metabolic reactions produce these compounds from the digestion of dietary protein, fat, and carbohydrates. It’s a pee test – Your pee literally takes a trip all the way to the USA and back and then gets analysed in depth for hours – It’s very important pee you know! offers a more detailed evaluation, with over 40 OAs. Patient should avoid apples, grapes (including raisins), pears, cranberries and their juices 48 hours prior to specimen collection. GPL-TOX - Toxic Organic Chemical Profile - Urine Test. Succinic acid is a key intermediate of both the Kreb’s cycle and the electron transport chain that generates adenosine triphosphate (ATP), the currency for most of the body’s energy transactions. (, Chronic inflammation can push the metabolism of tryptophan down the kynurenine pathway,  increasing levels of certain organic acids in the nervous system and urine, including (, The sample is then frozen and shipped to the laboratory, where organic acids are measured from the urine sample using liquid or gas chromatography-mass spectrometry (, Chromatography separates all of the different components found in the urine sample, while mass spectrometry is a tool used to identify and quantify each component by looking at its chemical makeup (, While it might be tempting to focus on individual OAs that show abnormal results, the overall pattern of abnormalities is more important (. Your practitioner will receive a report that lists the levels of individual organic acids as either being high, low, or within the normal range. DRIED BLOOD SPOT. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy. One urine sample provides over 70 metabolite markers which give us key information about what's going on inside your body. However, about 50% of these disorders are not detected until later in childhood, and some aren’t diagnosed until adulthood (16). diagnostic of any particular overgrowth but can help guide further testing decisions. So interesting! Some functional medicine doctors recommend a urine test called the organic acids test (OAT). What is the organic acid test or OAT? … OAT proponents state that high glutaric acid levels may reflect vitamin B2 deficiency. Many people with chronic illnesses and neurological … HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid) An abnormal phenylalanine metabolite produced by gastrointestinal bacteria of . They are not diagnostic of neurotransmitter levels in the brain or spinal cord. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. For more information on the Comprehensive OAT, look here. Well done. Organic Acids Test (OAT) - Urine Test When the body isn’t functioning optimally, organic acids in the urine can become elevated or depleted, depending on what is occurring. The cause … News & Updates See All › Provider Spotlight: Jenny Abercrombie, ND. The Great Plains Laboratory, Inc.11813 West 77th StreetLenexa, KS 66214, The Great Plains Laboratory, Inc., 11813 West 77th Street, Lenexa, KS, 66214, United States, GPL-TOX Profile (Toxic Non-Metal Chemicals). To collect your sample, you are required to urinate into a collection cup first thing in the morning, before you’ve had anything to eat or drink. Over 1,000 different organic acids have been detected in urine since this kind of testing started. Microbial Organic Acids Test (MOAT) MycoTOX Profile (Mold Exposure) Organic Acids Test (OAT) Porphyrins Profile . Negative stool tests for . In the same way, organic acids in our urine are byproducts of our metabolism and can give us information about how efficiently our body systems are performing. As a result, organic acids begin to build up and are excreted in the urine: Our urinary organic acid profiles can give us clues as to what’s happening in our bodies, and this is the basis of organic acid testing. Which is a urine Test ( OAT ) has become very popular amongst functional medicine doctors and dietitians it! Of mammals that are products of metabolism are genetic disorders that disrupt biochemical pathways in the urine of mammals are. Moat ) MycoTOX Profile ( Mold Exposure ) organic acids are most commonly analyzed in may. 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